Publications 2025 des investigateurs rhumatologues du Grand Ouest

Etude BACHELOR

Baricitinib in early polymyalgia rheumatica (BACHELOR): a randomised, double-blind, placebo-controlled, parallel-group trial
Alain Saraux , Guillermo Carvajal Alegria , Emmanuelle Dernis , Christian Roux , Christophe Richez , Alice Tison , Baptiste Quere, Sandrine Jousse-Joulin , Dewi Guellec , Thierry Marhadour , Patrice Kervarrec , Divi Cornec, Catherine Le Henaff , Sandra Lesven , Emmanuel Nowak , Aghiles Souki , Valérie Devauchelle-Pensec.

Lancet Rheumatol . 2025 Apr;7(4):e233-e242. doi: 10.1016/S2665-9913(24)00270-4. Epub 2025 Jan 13.

Etude STAR

Comparison of two strategies of glucocorticoid withdrawal in patients with rheumatoid arthritis in low disease activity (STAR): a randomised, placebo- controlled, double-blind trial
Adeline Ruyssen-Witrand , Clara Brusq, Maëva Masson , Vanina Bongard, Carine Salliot, Lucile Poiroux, Minh Nguyen, Christian Hubert Roux , Christophe Richez , Alain Saraux, Pascale Vergne-Salle, Jacques Morel, René-Marc Flipo , Muriel Piperno , Jacques-Eric Gottenberg , Hubert Marotte, Martin Soubrier , Laure Gossec, Philippe Dieudé, Slim Lassoued, Laurent Zabraniecki, Guillaume Couture, Jean Frédéric Boyer, Bénédicte Jamard, Yannick Degboe, Arnaud Constantin.
Ann Rheum Dis . 2025 Jan;84(1):49-59. doi: 10.1136/ard-2024-226620. Epub 2025 Jan 2.

PRECISESADS

Metabolomic and machine learning enhances patient diagnosis and stratification in systemic autoimmune diseases.
Perez-Sanchez C, Perez-Campoamor A, García-Delgado GD, Vellon-Garcia B, Llamas-Urbano A, Romero-Zurita L, Ortiz-Buitrago P, Merlo C, Cerdó T, Corrales S, Sanchez-Pareja I, Muñoz-Barrera L, Abalos-Aguilera MDC, Barbarroja N, Bolón-Canedo V, Ortega-Castro R, Calvo J, Ladehesa L, Aranda-Valera IC; PRECISESADS Clinical Consortium; Alarcon-Riquelme M, Aguirre MÁ, Escudero-Contreras A, Lopez-Pedrera
C. Comput Biol Med. 2025 Dec;199:111325. doi: 10.1016/j.compbiomed.2025.111325. Epub 2025 Nov 24.

Novel IgG and IgA autoantibodies validated in two independent cohorts are associated with disease activity and determine organ manifestations in systemic lupus erythematosus: implications for anti-LIN28A, anti-HMGN5, anti-IRF5, and anti-TGIF1.
Lindblom J, Lagutkin D, Sherina N, Idborg H, Beretta L, Borghi MO; PRECISESADS Clinical Consortium; Peyper JM, Barturen G, Jakobsson PJ, Alarcón-Riquelme ME, Nikolopoulos D, Parodis I. Ann Rheum Dis. 2025 Jul;84(7):1164-1179. doi: 10.1016/j.ard.2025.04.008. Epub 2025 May 9. PMID: 40348637

Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus.
Lindblom J, Barturen G, Beretta L, Toro-Domínguez D, Carnero-Montoro E, Borghi MO, Castillo J, Iacobaeus E, Enman Y; PRECISESADS Clinical Consortium; Mohan C, Alarcón-Riquelme ME, Nikolopoulos D, Parodis I. J Transl Autoimmun. 2025 Jun 11;11:100296. doi: 10.1016/j.jtauto.2025.100296. eCollection 2025 Dec. PMID: 40672966

BiomiX, a user-friendly bioinformatic tool for democratized analysis and integration of multiomics data.
Iperi C, Fernández-Ochoa Á, Barturen G, Pers JO, Foulquier N, Bettacchioli E, Alarcón-Riquelme M; PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium; Cornec D, Bordron A, Jamin C.
BMC Bioinformatics. 2025 Jan 10;26(1):8.

Identification of urinary bacterial genes as biomarkers for non-invasive diagnosis of renal lupus.
Pérez-Carrasco V, Soriano-Lerma A, Guzzi C, García-Martín ML, Tello MJ, Linde-Rodríguez Á, Sánchez-Martín V, Ortiz-González M; PRECISESADS Clinical Consortium; Gutiérrez-Fernández J, Alarcón-Riquelme ME, Soriano M, Marañón C, García-Salcedo JA.
Biomark Res. 2025 Sep 26;13(1):117. doi: 10.1186/s40364-025-00828-5.

Autre / Jeunes chercheurs

Maintenance of Remission After Tocilizumab Withdrawal in Patients With Glucocorticoid-Dependent Polymyalgia Rheumatica.
Chevet B, Souki A, Nowak E, Carvajal-Alegria G, Dernis E, Richez C, Truchetet ME, Wendling D, Toussirot E, Perdriger A, Gottenberg JE, Felten R, Fautrel B, Lohse A, Chiche L, Hilliquin P, Le Henaff C, Dervieux B, Direz G, Chary-Valckenaere I, Cornec D, Guellec D, Marhadour T, Saraux A, Devauchelle-Pensec V.
Arthritis Rheumatol. 2025 Oct;77(10):1416-1420. doi: 10.1002/art.43221. Epub 2025 Jul 29. PMID: 40339145

Usefulness of 18F-FDG PET-CT in detecting subclinical arteritis and cancer associated with polymyalgia rheumatica.
Le Madec A, Querellou S, Binard A, Saraux A, Quere B, Marhadour T, Jousse-Joulin S, Tison A, Cornec D, Guellec D, Devauchelle-Pensec V.
Joint Bone Spine. 2025 Jul 22;93(1):105950. doi: 10.1016/j.jbspin.2025.105950.

Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study.
Tison A, Jousse-Joulin S, Consigny M, Moog P, Hofauer B, Hachulla E, Lamotte C, Morel J, Mouterde G, Milic V, Bootsma H, Stel A, Fisher BA, Maybury M, Baer A, DiRenzo D, Kim HR, Min HK, Lee SS, Choi SE, Carvajal Alegria G, Boisramé S, Guellec D, Cornec D, Quéré B, Jonsson M, Hammenfors D, Saraux A, Devauchelle-Pensec V.
Rheumatology (Oxford). 2025 Jun 1;64(6):3739-3746. doi: 10.1093/rheumatology/keae690. PMID: 39700419

Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease.
Bettacchioli E, Cornec D, Gardien P, Quenehervé L, Guellec D, Tison A, Constantin A, Lequerre T, Bideau C, André AL, Capaldo C, Devauchelle-Pensec V, Dueymes M, Saraux A.
Rheumatol Ther. 2025 Apr;12(2):371-380. doi: 10.1007/s40744-024-00741-7.

Distinct Pathophysiologic Pathways Support Stratification of Sjögren's Disease Based on Symptoms, Clinical, and Routine Biological Data.
Nguyen Y, Beydon M, Gottenberg JE, Morel J, Perdriger A, Dernis E, Cornec D, Devauchelle-Pensec V, Sène D, Dieudé P, Couderc M, Fauchais AL, Larroche C, Vittecoq O, Salliot C, Hachulla E, Le Guern V, Mariette X, Seror R, Nocturne G.
Arthritis Rheumatol. 2025 Jul;77(7):876-883. doi: 10.1002/art.43096

GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica.
Jiemy WF, Zhang A, Abdulahad WH, Reitsema RD, van Sleen Y, Sandovici M, Alegria GC, Cornec D, Devauchelle-Pensec V, Hemon P, Quéré B, Boukhlal S, Roozendaal C, Kwee TC, Dasgupta B, Diepstra A, Heeringa P, Brouwer E, van der Geest KSM.
Ann Rheum Dis. 2025 May;84(5):833-843. doi: 10.1016/j.ard.2025.01.004.

Septic pubic symphysitis: newest radiological, microbiological, and outcome findings in a rare and difficult-to-treat infection.
Tabary S, Robin F, Darrieutort-Laffite C, Lautredoux F, Guggenbuhl P, Bart G.
Clin Microbiol Infect. 2025 Sep;31(9):1584-1586. doi: 10.1016/j.cmi.2025.04.028. Epub 2025 May 6.

COMOSPA

Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study.
Perez-Alamino R, Maldonado-Ficco H, Moltó A, Waimann C, Maldonado-Cocco J, Dougados M, Landewé R, van der Heijde D, Van den Bosch F; ASAS-COMOSPA study.
RMD Open. 2025 Jan 31;11(1):e004756. doi: 10.1136/rmdopen-2024-004756. PMID: 39890204

Registre ART

Do SMS/e-mail reminders increase influenza vaccination of rheumatoid arthritis patients under anti-TNF: a nested randomized controlled trial in the ART e-cohort.
Nguyen Y, Baron G, Hamamouche N, Belkhir R, Miconnet S, Soubrier M, Hostachy C, Thevenot P, Basch A, Truchetet ME, Claudepierre P, Dernis E, Marotte H, Flipo RM, Brocq O, Morel J, Fautrel B, Salliot C, Saraux A, Leske C, Schaeverbeke T, Ravaud P, Mariette X, Ruyssen-Witrand A, Seror R; ART Study Group§. Rheumatology (Oxford).
2025 May 1;64(5):2496-2504. doi: 10.1093/rheumatology/keae599. PMID: 39576675

COCORTICO

Evaluation of a nurse-led program for the prevention of complications of long-term glucocorticoids (COCORTICO): study protocol for a randomized trial.
Nicol S, Trin K, Simon LA, Nowak E, Duval O, Martin C, Abdelouahad S, Lengagne S, Chinchilla V, Gilet V, Briantais A, Saraux A, Cornec D, De Moreuil C, Tanguy ML, Guellec D.
Trials. 2025 Nov 17;26(1):510. doi: 10.1186/s13063-025-09236-4.

DESIR

Ten-year follow-up of degenerative spinal lesions on radiographs and MRI in axial spondyloarthritis: results of the DESIR (DEvenir des spondylarthropathies indifférenciées récentes) cohort.
Pina Vegas L, van Lunteren M, Loeuille D, Morizot C, Newsum E, Ramiro S, van Gaalen F, Saraux A, Claudepierre P, Feydy A, van der Heijde D, Reijnierse M.
Eur Radiol. 2025 Sep;35(9):5381-5391. doi: 10.1007/s00330-025-11432-4. Epub 2025 Mar 6.

Cohorte KHOALA

Health care practices in symptomatic knee and hip osteoarthritis patients: The KHOALA cohort.
Rat AC, Salmon JH, Ngueyon Sime W, Saraux A, Gard C, Guillemin F, Fautrel B.
Joint Bone Spine. 2025 Sep 2;93(1):105956. doi: 10.1016/j.jbspin.2025.105956.

SELECT-GCA

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis.
Blockmans D, Penn SK, Setty AR, Schmidt WA, Rubbert-Roth A, Hauge EM, Keen HI, Ishii T, Khalidi N, Dejaco C, Cid MC, Hellmich B, Liu M, Zhao W, Lagunes I, Romero AB, Wung PK, Merkel PA; SELECT-GCA Study Group.
N Engl J Med. 2025 May 29;392(20):2013-2024. doi: 10.1056/NEJMoa2413449.

NECESSITY

Primary Sjögren's Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren's Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI).
Bowman SJ, Seror R, Porcher R, Arends S, de Wolff L, Verstappen G, Devauchelle-Pensec V, Jousse-Joulin S, Baldini C, Bombardieri M, Pontarini E, Hueber W, Marvel J, Goswami P, Cornec D, Fisher BA, Nayar S, Barone F, Ng WF, Gottenberg JE, Bootsma H, Dörner T, Pincemin M, Bouillot C, Hammitt KM, Wahren-Herlenius M, van Roon J, Nocturne G, Laigle L, Moingeon P, Christodoulou A, Sreih AG, van Maurik A, Chen WH, Wisniacki N, Piatrova A, Jonsson R, Gergely P, Mariette X.
Ann Rheum Dis. 2025 Jul;84(7):1068-1089. doi: 10.1016/j.ard.2025.05.004.

ADVOCATE

Efficacy and safety of avacopan in patients aged 65 years and older with ANCA-associated vasculitis: a post hoc analysis of data from the ADVOCATE trial.
Geetha D, Pagnoux C, Sattui SE, Merkel PA, Weiner M, Draibe J, Faguer S, Bray S, Gurlin RE, Balcells-Oliver M, Bruchfeld A, Jayne DR; ADVOCATE Study Group.

Treatment With Avacopan in ANCA-Associated Vasculitis With Kidney Involvement.
Geetha D, Cortazar FB, Bruchfeld A, Kronbichler A, Karras A, Nakhoul GN, Merkel PA, Bray S, Bozeman AM, Jayne DRW; ADVOCATE Study Group.
Kidney Int Rep. 2025 Jun 2;10(8):2751-2765. doi: 10.1016/j.ekir.2025.05.041

VACIMRA

Effect of a 1-month methotrexate delay on pneumococcal vaccine immunogenicity and disease control in patients with early rheumatoid arthritis (VACIMRA): an open-label randomised trial.
Morel J, Dernis E, Roux C, Richez C, Brocq O, Fautrel B, Salliot C, Vittecoq O, Mariette X, Lioté F, Lassoued S, Gaujoux-Viala C, Constantin A, Soubrier M, Devauchelle-Pensec V, Goeb V, Gottenberg JE, Marotte H, Moulard AR, Daien C, Mouterde G, Lukas C, Pissarra J, Huguet H, Launay O, Galtier F, Picot MC; I-REIVAC; CRI-IMIDIATE French Clinical Research Networks.
Lancet Rheumatol. 2025 Oct;7(10):e675-e686. doi: 10.1016/S2665-9913(25)00071-2

APACHE

Early peripheral psoriatic arthritis: Baseline features of the first 186 patients in the French Nationwide APACHE Cohort.
Claudepierre P, Gaujoux-Viala C, Constantin A, Berenbaum F, Combe B, Devauchelle V, Goupille P, Richette P, Wendling D, Mouterde G, Pascart T, Razat B, Audureau E, Jousse-Joulin S, Gossec L.
Joint Bone Spine. 2025 Dec;92(6):105930. doi: 10.1016/j.jbspin.2025.105930. Epub 2025 May 27

REGATE

Risk of cancer in patients with rheumatoid arthritis under tocilizumab: Data from the French national registry REGATE.
Morel J, Wetzman A, Wendling D, Soubrier M, Hoang S, Briançon D, Roth O, Goupille P, Gottenberg JE, Mariette X, Lukas C; French Society of Rheumatology, the investigators participating in REGATE registry.
Joint Bone Spine. 2025 Oct;92(5):105900. doi: 10.1016/j.jbspin.2025.105900. Epub 2025 Apr 4.

METHOFRACT

METHOFRACT, a methotrexate osteopathy multicentre cohort study.
Robin F, Ghossan R, Mehsen-Cetre N, Triquet L, Larid G, Coiffier G, Mina M, Pickering ME, Barthe C, Paccou J, Herman J, Massy E, Roitg I, Branquet M, Lasnier Siron J, Guillouard M, Desmonet Trousset C, Aubrun A, Godfrin B, Hauzeur JP, Chatelus E, Koumakis E, Legrand JL, Schaeverbeke T, Leloix A, Masson M, Nicolau J, Ghiringhelli C, Decrock M, Durel CA, Bouvard B, Cortet B, Casadepax-Soulet C, Malaise O, Javier RM, Briot K, Guggenbuhl P.
RMD Open. 2025 Sep 25;11(3):e005941. doi: 10.1136/rmdopen-2025-005941.

CAR-T cells

CAR T-cell therapy in autoimmune diseases: where are we and where are we going?
Scherlinger M, Nocturne G, Radic M, Launay D, Richez C, Bousso P, Forcade E, Meyer A, Jorgensen C, Bigenwald C, Cornec D, Sibilia J, Choquet S, Martin T, Belot A, Jouret M, Bitoun S, Amoura Z, Hermine O, Mariette X, Donnadieu E, Avouac J; Club for Innovative Immunotherapies in Immune-mediated Inflammatory diseases (C3I).
Lancet Rheumatol. 2025 Jun;7(6):e434-e447. doi: 10.1016/S2665-9913(24)00377-1. Epub 2025 Mar 26

La SRO existe depuis 1977, soit plus de 40 ans. Son action principale est la formation des rhumatologues de tous âges et de tous horizons, libéraux et hospitaliers, de l’ouest de la France.